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baby If you are at risk for Sudden Infant Death Syndrome (SIDS), you can identify it using biochemical markers. This is due to a new study published in Lancet’s eBioMedicine.
According to the Mayo Clinic, SIDS is an unexplained death of a seemingly healthy baby under the age of one, usually during sleep. According to the CDC report, SIDS accounted for 37% of sudden infant deaths in the United States in 2019.
Researchers investigating the cause of SIDS at the West Mead Children’s Hospital (CHW) Australia They said they identified the first biochemical markers that could help detect babies at higher risk of sudden infant death syndrome while they were still alive.
Dr. Carmel Harrington, an emeritus researcher who led the study, said the findings were groundbreaking. Harrington said the study provided an explanation for SIDS and hopes for the prevention of deaths associated with this mysterious condition.
“It’s a nightmare for all parents that an apparently healthy baby doesn’t fall asleep, and until now there was no way to know which baby would die, but it’s no longer the case. Earlier I found the first marker to indicate a vulnerability, “Harrington said in a news release.
According to the study, Australian researchers analyzed the levels of a specific enzyme called butyrylcholinesterase (BChE) in 722 dried blood spots (DBS) taken at birth as part of a newborn screening program. They measured BChE levels in infants who died from SIDS and other causes and compared them to 10 surviving infants of the same date of birth and gender, respectively.
According to a published report, researchers found that infants who died of SIDS had lower levels of BChE compared to sudden infant death syndrome and other non-SIDS-related sudden infant death syndrome.
“Abnormal-The previously unidentified cholinergic deficiency identified by BChEsa is present at birth in SIDS infants and concludes that it represents a specific premortal measurable vulnerability. “The researchers said.
Researchers explained that BChE plays an important role in the wakefulness pathway of the brain. They further explained that BChE deficiency may indicate a defect in the baby’s arousal, which reduces their ability to wake up and respond to the external environment and makes them more susceptible to SIDS. bottom.
“Baby has a very powerful mechanism to tell you when you’re not happy. Usually, when you’re faced with a life-threatening situation, such as having difficulty breathing while sleeping because your baby is on your stomach, your baby Cries with excitement. This study shows that some babies do not show this same strong arousal response, “Harrington said.
Dr. Matthew Harris, a pediatrician for emergency medicine at Cohen Children’s Medical Center / Northwell Health in Long Island, NY, was not involved in the study, although Fox news“The results of this study are interesting and important. The sample size is limited, but studies seem to show that low levels of this enzyme increase the risk of sudden infant death syndrome. Important thing. In addition, this may provide early screening of perinatal risk factors and the opportunity for scientists and doctors to discover interventions. ”
Harris added, “We are currently screening for dozens of metabolic disorders as part of the newborn screening process. If this proves to be a true relevance, it will be added to the list of disorders that can be detected early. May prevent progression. Severe illness. “
In a news release, Harrington, who not only led the study but also experienced the loss of his baby in SIDS nearly 30 years ago, has so far recognized health experts as the cause of the baby’s lack of arousal. Said he wasn’t. “Once we know that BChE is involved, we can start changing the results of these babies and make SIDS a thing of the past.”